Manoj Mathew et al. in their research, show how elevated FFA behave like a glue material , stuck to the inner surface of the blood vessels, increase cardiovascular risk, associates with endothelial activation, leads to transport of metabolic substrates and cells between the blood and the interstitial space and initiates the formation of atherosclerotic plaques and long atherosclerotic lesions considered to be the main reason in stenosis and obstructions in the cardiovascular system, known to be the main reason for heart attacks and brain strokes.
Diabetes and Atherosclerosis
According to Devjit, high concentrations of plasma FFA, reduces the Insulin-stimulated glucose uptake, it also lead to impairment in endothelium-dependent and Insulin-mediated vasodilatation.
In the research of G. Boden, they stressed the fact that chronically elevated plasma FFA appear to have pathophysiological consequences, it linked with the onset of peripheral and hepatic insulin resistance.
In the Guenther Boden, M.D, they show that Obesity is closely associated with insulin resistance and stress the scientific and medical fact that both obesity and insulin resistance lead to type 2 diabetes.
In the research of Meredith Hawkins, they highlights the role of increased circulating free fatty acids in inhibition of both hepatic and peripheral insulin action, they also show that elevated FFA leads to a poor control on type 2 diabetes .
High blood pressure (hypertension)
According to Anne Fagot- Campagna, the insulin resistance, stimulated by the elevated levels of FFA have a direct effect on hypertension, therefore, high Concentrations of FFA considered as a risk factor for hypertension.